The lysosome and neurodegenerative diseases.
نویسندگان
چکیده
It has long been believed that the lysosome is an important digestive organelle. There is increasing evidence that the lysosome is also involved in pathogenesis of a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Abnormal protein degradation and deposition induced by lysosomal dysfunction may be the primary contributor to age-related neurodegeneration. In this review, the possible relationship between lysosome and various neurodegenerative diseases is described.
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عنوان ژورنال:
- Acta biochimica et biophysica Sinica
دوره 41 6 شماره
صفحات -
تاریخ انتشار 2009